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In addition to HIFs, hypoxia also induced E2F transcription factor 7(E2F7) to increase the transcription of splicing factor quaking ( QKI ), which promotes the biogenesis of circBCAR3 , a circular RNA highly expressed in the esophageal cancer cells [121]

doi: 10.1046/j.1524-475X.2003.11605.x

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Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway